Lecture Notes

 

LEC # TOPICS SLIDES ANNOTATED
1

Overview of Course, Orientation to Current Approaches and Types of Molecularly-designed Biomaterials

Biodegradable Polymeric Solids

Chemistry and Physical Chemistry of Hydrolysis

Links between Materials Structure and Hydrolysis Mechanisms

 (PDF - 1.6 MB) (This resource may not render correctly in a screen reader.PDF - 1.7 MB)
2

Biodegradable Polymeric Solids (cont.)

Factors Controlling Polymer Degradation Rates

Theory of Solid Polymer Erosion

Tailoring Degradable Polymer Structure and Composition

 (PDF) (This resource may not render correctly in a screen reader.PDF)
3

Controlled Release Devices

Types of Controlled Release Devices

Degradable Materials in Controlled Release Devices

Physical Chemistry Principles in Delivering Small Molecules vs. Proteins

 (PDF) (This resource may not render correctly in a screen reader.PDF)
4

Controlled Release Devices (cont.)

Theory of Drug Release in Eroding Systems

 (PDF) (This resource may not render correctly in a screen reader.PDF - 1.1 MB)
5

Case Studies in Complex Controlled Release

Pulsatile Release from Programmed Eroding Systems

Controlled Release Microchips

Combining Drug Delivery with Tissue Engineering

    
6

Hydrogels as Biomaterials

Hydrogel Structure and Physical Chemistry

Methods of Polymerization

 (PDF - 2.0 MB)  
7

Hydrogels as Biomaterials (cont.)

Theory of Hydrogel Swelling

Physical Hydrogels

  • Ionic and Hydrogen Bonding in Gels
  • Association of Amphiphilic Block Copolymers
 (PDF) (This resource may not render correctly in a screen reader.PDF)
8

Hydrogels as Biomaterials (cont.)

Polyelectrolyte Hydrogels

Coacervates

Polyelectrolyte Multi-layers

 (PDF) (This resource may not render correctly in a screen reader.PDF)
9

Hydrogels as Biomaterials (cont.)

Theory of Polyelectrolyte Gel Swelling

 (PDF - 1.1 MB) (This resource may not render correctly in a screen reader.PDF - 1.2 MB)
10

Hydrogels as Biomaterials (cont.)

Applications of Hydrogels: Molecular Imprinting

Applications of Hydrogels: Glucose-sensitive Drug Delivery

Kinetics of Drug Diffusion through Hydrogels

 (PDF - 1.1 MB) (This resource may not render correctly in a screen reader.PDF - 1.2 MB)
11

Engineering Biological Recognition of Biomaterials

Biological Recognition in Vivo

Protein-resistant and Cell-resistant Surfaces

Engineering Recognition of Biomaterials: Adhesion and Migration

 (PDF - 2.3 MB) (This resource may not render correctly in a screen reader.PDF - 1.8 MB)
12

Engineering Biological Recognition of Biomaterials (cont.)

Enzymatic Recognition of Biomaterials

Cytokine Signaling from Biomaterials

 (PDF - 1.8 MB) (This resource may not render correctly in a screen reader.PDF - 2.0 MB)
13

Engineering Biological Recognition of Biomaterials (cont.)

Mimicking Cell-cell Contacts with Surfaces

 (PDF - 2.9 MB) (This resource may not render correctly in a screen reader.PDF - 3.4 MB)
14

Bioceramics and Biocomposites

Introduction to Biological Approaches to Biomineralization

Interfacial Biomineralization

 (PDF - 1.6 MB)

(This resource may not render correctly in a screen reader.PDF - 2.2 MB)
15

Bioceramics and Biocomposites (cont.)

Biological Control of Mineralization within Vesicles

Biomimetic Syntheses: Microemulsion and Micellar Reactions Organic Templating of Inorganic Biomaterials: Natural and Synthetic Approaches

 (PDF) (This resource may not render correctly in a screen reader.PDF - 1.7 MB)
16

Bioceramics and Biocomposites (cont.)

Theory of Controlled Nucleation

Bone Structure and Bone Biomimesis

Biocomposites in Device Applications and Drug Delivery

 (PDF - 1.0 MB) (This resource may not render correctly in a screen reader.PDF - 2.2 MB)
17

Molecular Devices

Molecular Switches via Proteins and 'Smart' Polymers

  • Temperature, pH, and Light-sensitive Switches

Molecular Motors

  • Kinesin-based Molecular Shuttles
  • ATP Synthase-based Nano-rotors
 (PDF - 1.4 MB) (This resource may not render correctly in a screen reader.PDF - 1.5 MB)
18

Nanoparticle and Microparticle Biomolecule Drug Carriers

Pro-drugs, Micelles, Liposomes, Polymerosomes, Nanoparticles, and Microparticles

Delivery of Drugs to Tissues via Systemic Circulation

Materials for Anti-Cancer Drug Delivery

 (PDF - 4.1 MB) (This resource may not render correctly in a screen reader.PDF - 4.6 MB)
19

Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.)

Barriers to Systemic / Oral Delivery and Delivery of Molecules to Tissues

'Stealth' Particles

  • Theory of Protein-resistant Particles

Experimental Function of Long-circulating Carriers and PEGylated Compounds

 (PDF - 2.0 MB) (This resource may not render correctly in a screen reader.PDF - 2.2 MB)
Focus Topic: Integrating Biological Knowledge Into Biomaterials Design For Vaccines
20

Basic Biology of Vaccination and Viral Infections

Rudiments of Adaptive Immunity: The Basis of Vaccination

Viral Infections

 (PDF) (This resource may not render correctly in a screen reader.PDF - 1.3 MB)
21

Basic Biology of Vaccination and Viral Infections (cont.)

Vaccination Against Viruses: Parallels between Immunization and Infection

 (PDF) (This resource may not render correctly in a screen reader.PDF - 1.5 MB)
22

Drug Targeting and Intracellular Drug Delivery for Vaccines

Targeting Nano-carriers and Micro-carriers to Specific Cell Types

Chemistry of Antibodies for Targeting

Pathways of Intracellular Transport

 (PDF) (This resource may not render correctly in a screen reader.PDF)
23

Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.)

Mechanisms of Intracellular Delivery

Mimicking Viral Entry Strategies

 (PDF - 2.8 MB) (This resource may not render correctly in a screen reader.PDF - 3.1 MB)
24

DNA Vaccines

Gene Therapy and DNA Immunization

Mechanisms of DNA Vaccines

 (PDF - 4.1 MB) (This resource may not render correctly in a screen reader.PDF - 4.7 MB)
25

DNA Vaccines (cont.)

Delivery Systems for DNA

Systemic vs. Local Delivery