| LEC # | TOPICS | INSTRUCTORS | LECTURE NOTES |
|---|---|---|---|
| I. Principles Of Implant Design (Working Paradigms) | |||
| 1 | Clinical Problems Requiring Implants for Solution | I. V. Yannas / M. Spector |
Overview Slides (PDF - 1.2 MB) Four Design Principles for Medical Devices (PDF) |
| 2 | Principles of Implant Design / Design Parameters: Permanent versus Absorbable Devices | I. V. Yannas / M. Spector | |
| 3 | The Missing Organ and its Replacement | I. V. Yannas | The Problem of the Missing Organ (PDF) |
| 4 | Criteria for Materials Selection | I. V. Yannas | |
| 5 | Tissue Engineering I: Scaffolds | M. Spector |
Tissue Engineering I: Overview (PDF - 1.4 MB) Tissue Engineering II: Scaffolds (PDF - 1.4 MB) |
| 6 | Tissue Engineering II: Cells and Regulators | M. Spector |
Tissue Engineering III: Growth Factors and Genes (PDF - 1.3 MB) Tissue Engineering IV: Stem Cells (PDF - 1.2 MB) |
| 7 | Case Study of Organ Regeneration | I. V. Yannas | Design Case Study: Device for Partial Regeneration of Skin (PDF) |
| II. Design Parameters | |||
| 8 | Design Specifications: Biomaterials Survey | M. Spector |
Biomaterials Survey (PDF) Implant Fixation, Mechanical Stability and Modulus Matching (PDF - 1.2 MB) |
| Quiz | |||
| 9 | Biocompatibility: Local and Systemic Effects | M. Spector | Biocompatibility (PDF - 1.3 MB) |
| 10 | Design Specifications: Tissue Bonding and Modulus Matching | M. Spector | |
| 11 | Degradation of Devices: Natural and Synthetic Polymers | I. V. Yannas | |
| 12 | Biocompatibility: Scar Formation and Contraction | I. V. Yannas | Scar Formation Around Implants (PDF) |
| 13 | Degradation of Devices: Corrosion and Wear | M. Spector | Degradation of Devices: Corrosion and Wear (PDF) |
| 14 | Federal Regulation of Devices I | M. Spector |
Federal Regulation of Medical Devices (PDF - 1.2 MB) Recommended Biocompatibility Testing and Regulation of Tissue Engineered Products (PDF - 1.0 MB) Summary of Federal Regulatory Issues and Clinical Trials (PDF - 1.1 MB) |
| 15 | Oral Presentations of Proposals for Design II | I. V. Yannas / M. Spector | |
| 16 | Federal Regulation of Devices II | M. Spector | |
| III. Design Solution In-use | |||
| 17 | Scaffolds for Cartilage Repair | S. Vickers | Statistics: Type I and Type II errors (PDF) |
| 18 | Implants for Bone | M. Spector | Bone Substitute Materials and Tissue Engineering (PDF - 1.4 MB) |
| 19 | Implants for Plastic Surgery | Dr. D. P. Orgill | |
| 20 | Cardiovascular Prostheses: Heart Valves and Blood Vessels | Dr. F. Schoe | |
| 21 | Devices for Nerve Regeneration | I. V. Yannas | |
| 22 | Musculoskeletal Soft Tissues: Meniscus, Intervertebral Disk | M. Spector | |
| 23 | Dental and Otologic Implants | M. Spector | Dental Tissue Engineering (PDF) |
| 24 | Other Devices: Spinal Cord, Heart Lung | M. Spector | |
| 25 | Final Oral Presentation of Designs (Mock FDA Panel) | ||