| SES # | TOPICS | READINGS |
|---|---|---|
| 1 | Introduction and Overview: Social and Ethical Questions | Fischer, Michael M. J. "Four Frameworks for Social and Ethical Questions." 2005. (PDF) |
| 2 | Polymers for Drug Delivery and Tissue Engineering - Prof. Robert Langer, Kenneth J. Germeshausen Professor of Chemical Engineering, MIT |
 Jasanoff, Sheila. Designs on Nature: Science and Democracy in Europe and the United States. Princeton, NJ: Princeton University Press, 2005, introduction, chapter 1, and 2. ISBN: 9780691118116.Langer, R., and D. A. Tirell. "Designing materials for biology and medicine." Nature 428, no. 6982 (April 1, 2004): 487-92. Langer, R. "Where a Pill Won't Reach." Sci Am 288, no. 4 (April 2003): 50-7. |
| 3 | Embodiment and Structural Biology, Phenomenology of Medicine - Natasha Myers (STS Program, MIT) | Myers, Natasha. "Embodiments and the Body-Work of Modeling in Protein Crystallography." 2005. (Manuscript) Good, Byron. "The experience of being a medical student." Chapter 3 in Medicine, Rationality and Experience: An Anthropological Perspective. Cambridge, UK; New York, NY: Cambridge University Press, 1993. ISBN: 9780521415583. Prentice, Rachel. "The Anatomy of a Surgical Simulation: The Mutual Articulation of Bodies in and through the Machine." Social Studies of Science 35, no. 6 (2005): 837-866. |
| 4 | Tissue Engineering - Dr. Joseph Vacanti, John Homans Professor of Surgery and Director of Pediatric Transplanation, MGH | Vacanti, J. P., and R. Langer. "Tissue Engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplanation." Lancet 354 (1999): 32-34. (Suppl 1) Langer, R., and J. P. Vacanti. "Tissue Engineering." Science 260, no. 5110 (May 14, 1993): 920-6. |
| 5 | Clinical Narratives - Prof. Mary-Jo DelVecchio Good, Professor of Social Medicine, HMS |
Good, M. J., I. Kuter, S. Powell, et al. "Medicine on the Edge: Conversations with Oncologists." Technoscientific Imaginaries: Conversations, Profiles, and Memoirs. Edited by George E. Marcus. Chicago, IL: University of Chicago Press, 1995. ISBN: 9780226504438. Good, Mary-Jo DelVecchio. American Medicine: the Quest for Competence. Berkeley, CA: University of California Press, 1995, chapter 8, p. 265. ISBN: 9780520088962. Good, M. J. "The biotechnical embrace." Cult Med Psychiatry 25, no. 4 (December 2001): 395-410. |
| 6 | Photomedicine and Non-invasive Technologies - Dr. R. Rox Anderson, Director Wellman Center for Photomedicine and Professor of Dermatology, MGH, HMS, HST | Pitsillides, C. M., E. K. Joe, X. Wei, R. R. Anderson, and C. P. Lin. "Selective cell targeting with light-absorbing microparticles and nanoparticles." Biophys J 84, no. 6 (June 2003): 4023-4032. Middelkamp-Hup, M. A., I. Sanchez-Carpintero, S. Kossodo, P. Waterman, S. Gonzalez, M. C. Mihm, Jr., and R. R. Anderson. "Photodynamic therapy for cutaneous proliferative vascular tumors in a mouse model." J Invest Dermatol 121, no. 3 (September 2003): 634-639. Manstein, D., G. S. Herron, R. K. Sink, H. Tanner, and R. R. Anderson. "Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury." Lasers Surg Med 34, no. 5 (2004): 426-438. Yaroslavsky, A. N, J. Barbosa, V. Neel, C. DiMarzio, and R. R. Anderson. "Combining multispectral polarized light imaging and confocal microscopy for localization of nonmelanoma skin cancer." J Biomed Opt 10, no. 1 (January-February 2005): 14011. |
| 7 | Multidisciplinary Research - Prof. Brian Seed, Professor of Genetics and Health, Science and Technology, Director of Thematic Center for Computational Biology, MGH, HMS, HST | Yang, Y., and B. Seed. "Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes." Nat Biotechnol 21, no. 4 (April 2003): 447-451. Randow, F., and B. Seed. "Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability." Nat Cell Biol 3, no. 10 (October 2001): 891-6. Kowalczyk, Liz. "Lucrative Licensing Deals with Drugs, Biotech Firms are Raising Ethics Issues for Hospitals." Boston Globe (March 24, 2002). "NeoGenesis and Massachussetts General Hospital Announce Drug Discovery Collaboration Agreement." PRNewswire - Neogenesis, July 23, 2002. |
| 8 | Angiogensis; Translation from Bench to Clinic - Dr. Judah Folkman, Andrus Professor of Pediatric Surgery and Professor of Cell Biology, HMS |
Folkman, J. "Angiogenesis." In Harrison's Textbook of Internal Medicine. Edited by E. Braunwald, A. S. Fauci, D. L. Kasper, S. L. Hauser, D. L. Longo, and J. L. Jameson. 15th ed. New York, NY: McGraw-Hill, 2001, pp. 417-530. ISBN: 9780079136862 (set). ISBN: 9780070072732 (v. 1), and ISBN: 9780070072749 (v. 2). ———. "Fighting cancer by attacking its blood supply." Sci Am 275, no. 3 (September 1996): 150-4. ———. "Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis." N Engl J Med 333, no. 26 (December 28, 1995): 1757-63. |
| 9 | Stem Cells - Dr. George Q. Daley, M.D./Ph.D., Associate Professor of Biological Chemistry and Molecular Pharmacology, HMS, Children's Hospital, Brigham and Women's, and Dana-Farber | Daley, G. Q. "Customized human embryonic stem cells." Nat Biotechnol 23, no. 7 (July 2005): 826-8. Daley, G. Q., M. J. Sandel, and J. D. Moreno. "Stem cell research: science, ethics and policy." Med Ethics (Burlington, MA) 12, no. 1 (Winter 2005): 5. Daley, G. Q. "Missed opportunities in embryonic stem-cell research." N Engl J Med 351, no. 7 (August 12, 2004): 627-8. Committee on Guidelines for Human Embryonic Stem Cell Research, Institute of Medicine and National Research Council. "Guidelines for human embryonic stem cell research." Washington, DC: National Academies Press, 2005. |
| 10 | Facilitating Multidisciplinary Research at MGH - Dr. John Parrish, Director MGH-Harvard Cutaneous Biology Research Center, Director of CIMIT, Chief Dermatology Service, MGH, and founding Director Wellman Center for Photomedicine |
Stokes, Donald E. Pasteur's Quadrant: Basic Science and Technological Innovation. Washington, DC: Brookings Institution Press, 1997, chapter 1. ISBN: 9780815781783. Abelmann, Walter H., ed. Harvard-MIT Division of Health Sciences and Technology: The First 25 Years 1970-1995. Cambridge, MA: The Division, 2004. ISBN: 9780674014589. |
| 11 | Organ Transplanation in Turkey, Ethical Models of Organ Donation - Aslihan Sanal, STS Program, MIT | Sanal, Aslihan. ""Robin Hood" of techno-turkey or organ trafficking in the state of ethical beings." Culture, Medicine, and Psychiatry 28, no. 3 (September 2004): 281-309. |
| 12 | Ethics in Medicine - Prof. Dan Brock, Prof. of Social Medicine and Director of the Division of Medical Ethics, Harvard Medical School | |
| 13 | Wrap-up |