Session 12: Respiration: Electron Transport and Oxidative Phosphorylation

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Lecture Topics

The Role of Electron Transport to Generate Proton Gradients Mobile e⊖ Carriers Integral Membrane Proteins as Electron Conduits Thermodynamics of ATP Synthesis

Readings

• Chapter 18: Electron Transport and Oxidative Phosphorylation
  • The Mitochondrion
  • Oxidative Phosphorylation
  • Control of Oxidative Metabolism

Lecture Video: PLP Chemistry

Pyridoxal Phosphate (PLP), an essential metabolism cofactor derived from Vitamin B6, is involved in many chemical transformations. This video summarizes the most important ones and shows how to write the curved arrow mechanisms for these transformations.

Lecture Video: Respiration: Electron Transport and Oxidative Phosphorylation

In this video, Professor Essigmann returns to the topic of respiration. He details how to convert the electron transport potential of NADH and FADH2 into the phosphate transfer potential of ATP.

• Storyboards 12–13 (PDF)

Problem Set & Solutions

• Problem Set 8 (PDF)
• Solutions to Problem Set 8 (PDF)

Problem Solving Video: Problem Set 8, Problem 2: Bioenergetics of the Electron Transport Chain

In this problem, Dr. Fedeles focuses on the electron transport chain. This fundamental redox process converts the chemical energy of the covalent bonds into an electrochemical gradient.

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