Lec #	Topics	Instructors
1	Reaction models; simple kinetics & equilibria	Bob Sauer
2	Analyzing kinetic & equilibria experiments
3	Free energy, entropy, enthalpy & cycles
4	Forces, hydrophobic effect, chelate effect
5	Molecular structure and dynamics
6	Physical properties of proteins and nucleic acids	Tania Baker
7	Principles and practice of protein purification
8	Principles and practice of protein purification (cont.)
9	EXAM 1
10	Domain & subunit organization; molecular weight determination	Tania Baker
11	Macromolecular interactions: specificity, affinity and energetics
12	Macromolecular interactions: specificity, affinity and energetics (cont.)
13	Enzyme catalysis: kinetics	Frank Solomon
14	Mechanism of enzyme catalyzed reactions
15	inhibition and intermediates
16	Mechanism of enzyme catalyzed reactions: chemistry
17	Mechanism of enzyme catalyzed reactions: partitioning & exchange
18	Mechanism of enzyme catalyzed reactions: binding energy
19	Specificity of catalysis: energetics and consequences
20	Specificity of catalysis: energetics and consequences (cont.)
21	EXAM 2
22	Coupled vectorial processes: making ATP	Frank Solomon
23	Coupled vectorial processes: pumps
24	Coupled vectorial processes: OxPhos, morphology to enzymology
25	Coupled vectorial processes: processivity
26	Coupled vectorial processes: Motors; Polymers – origins & consequences of structural & thermodynamic polarity
27	Coupled vectorial processes: motors; structural & thermodynamic polarity
28	Coupled vectorial processes: protein folding
29	Review Session
30	FINAL EXAM