Readings

Course readings.
WEEK #	TOPICS	READINGS
1	Introduction and course overview See the Lecture Summary
2	X chromosome genetics: Flies were first on the scene See the Lecture Summary	Paper 1 Morgan, T. H. "Sex Limited Inheritance in Drosophila." Science 32 (1910): 120-122. (PDF) Paper 2 Sturtevant, A. H. "The Linear Arrangement of Six Sex-linked Factors in Drosophila, as Shown by Their Mode of Association." Journal of Experimental Zoology 14 (1913): 43-59. (PDF)
3	Medical diseases: Sex reversal and the X See the Lecture Summary	Paper 1 Petit, C., A. de la Chapelle, J. Levilliers, S. Castillo, B. Noel, and J. Weissenbac. "An Abnormal Terminal X-Y Interchange Accounts for Most but not all Cases of Human XX Maleness." Cell 49 (1987): 595-602. Paper 2 Brown, T. R., D. B. Lubahn, E. M. Wilson, D. R. Joseph, F. S. French, and C. J. Migeon. "Deletion of the Steroid-binding Domain of the Human Androgen Receptor Gene in One Family With Complete Androgen Insensitivity Syndrome: Evidence for Further Genetic Heterogeneity in this Syndrome." PNAS 85 (1988): 8151-5.
4	Dosage compensation I: X-inactivation in mammals See the Lecture Summary	Paper 1 Lyon, M. F. "Gene Action in the X-Chromosome of the Mouse (Mus musculus L.)." Nature 190 (1961): 372-3. Paper 2 Nguyen, D. K., and C. M. Disteche. "Dosage Compensation of the Active X Chromosome in Mammals." Nature Genetics 38 (2006): 47-53.
5	Dosage compensation II: X-ceptions See the Lecture Summary	Paper 1 Jegalian, K., and D. C. Page. "A Proposed Path by Which Genes Common to Mammalian X and Y Chromosomes Evolve to Become X Inactivated." Nature 394 (1998): 776-80. Paper 2 Huynh, K. D., and J. T. Lee. "Inheritance of a Pre-inactivated Paternal X Chromosome in Early Mouse Embryos." Nature 426 (2003): 857-62.
6	Dosage compensation III: Doubling and spreading See the Lecture Summary	Paper 1 Bashaw, G. J., and B. S. Baker. "The Regulation of the Drosophila msl-2 Gene Reveals a Function for Sex-lethal in Translational Control." Cell 89 (1997): 789-98. Paper 2 Kelley, R. L., V. H. Meller, P. R. Gordadze, G. Roman, R. L. Davis, and M. I. Kuroda. "Epigenetic Spreading of the Drosophila Dosage Compensation Complex from roX RNA Genes into Flanking Chromatin." Cell 98 (1999): 513-22.
7	Dosage compensation IV: Half and half in worms See the Lecture Summary	Paper 1 Meyer, B. J., and L. P. Casson. "Caenorhabditis Elegans Compensates for the Difference in X Chromosome Dosage Between the Sexes by Regulating Transcript Levels." Cell 47 (1986): 871-81. Paper 2 Csankovszki, G., P. McDonel, and B. J. Meyer. "Recruitment and Spreading of the C. Elegans Dosage Compensation Complex Along X Chromosomes." Science 303 (2004): 1182-5.
8	A highly conserved chromosome See the Lecture Summary	Paper 1 Ross, M. T., et al. "The DNA Sequence of the Human X Chromosome." Nature 434 (2005): 325-37. Paper 2 Emerson, J. J., H. Kaessmann, E. Betran, and M. Long. "Extensive Gene Traffic on the Mammalian X Chromosome." Science 303 (2004): 537-40.
9	Gene content: A "sexy" X See the Lecture Summary	Paper 1 Wang, P. J., J. R. McCarrey, F. Yang, and D. C. Page. "An Abundance of X-linked Genes Expressed in Spermatogonia." Nature Genetics 27 (2001): 422-6. Paper 2 Sturgill, D., Y. Zhang, M. Parisi, and B. Oliver. "Demasculinization of X Chromosomes in the Drosophila Genus." Nature 450 (2007): 238-41.
10	Divergence of the X and Y chromosomes See the Lecture Summary	Paper 1 Lahn, B. T., and D. C. Page. "Four Evolutionary Strata on the Human X Chromosome." Science 286 (1999): 964-7. Paper 2 Grutzner, F., W. Rens, E. Tsend-Ayush, N. El-Mogharbel, P. C. O'Brien, R. C. Jones, M. A. Ferguson-Smith, and J. A. Marshall Graves. "In the Platypus a Meiotic Chain of Ten Sex Chromosomes Shares Genes with the Bird Z and Mammal X Chromosomes." Nature 432 (2004): 913-7.
11	Hybrids I: Haldane's rule See the Lecture Summary	Paper 1 Masly, J. P., and D. C. Presgraves. "High-resolution Genome-wide Dissection of the Two Rules of Speciation in Drosophila." PLoS Biology 5 (2007): e243. Paper 2 Phadnis, N., and H. A. Orr. "A Single Gene Causes Both Male Sterility and Segregation Distortion in Drosophila Hybrids." Science 323 (2009): 376-9.
12	Hybrids II: Are hybrids a step in the formulation of new species? See the Lecture Summary	Paper 1 Good, J. M., M. D. Dean, and M. W. Nachman. "A Complex Genetic Basis to X-linked Hybrid Male Sterility Between Two Species of House Mice." Genetics 179 (2008): 2213-28. Paper 2 Patterson, N., D. J. Richter, S. Gnerre, E. S. Lander, and D. Reich. "Genetic Evidence for Complex Speciation of Humans and Chimpanzees." Nature 441 (2006): 1103-8.
13	Course summary See the Lecture Summary