| WEEK # | TOPICS | READINGS |
|---|---|---|
| 1 |
Introduction | |
| 2 |
Alien invasion: How Toxoplasma secretly enters host cells |
Morisaki, J. H., J. E. Heuser, et al. "Invasion of Toxoplasma Gondii Occurs by Active Penetration of the Host Cell." Journal of Cell Science 108, no. 6 (1995): 2457–64. Mordue, D. G., et al. "Invasion by Toxoplasma Gondii Establishes a Moving Junction that Selectively Excludes Host Cell Plasma Membrane Proteins on the Basis of their Membrane Anchoring." The Journal of Experimental Medicine 190, no. 12 (1999): 1783–92. (The Rockefeller University Press) |
| 3 |
Make yourself at home: Intracellular survival in the parasitophorous vacuole |
Eksi, S., and K. C. Williamson. "Protein Targeting to the Parasitophorous Vacuole Membrane of Plasmodium Falciparum." Eukaryotic Cell 10, no. 6 (2011): 744–52. (American Society for Microbiology) Nadipuram, S. M., E. W. Kim, et al. "In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis." mBio 7, no. 4 (2016): e00808–16. (American Society for Microbiology) |
| 4 |
How parasites transport proteins and nutrients across membranes |
Elsworth, B., K. Matthews, et al. "PTEX is an Essential Nexus for Protein Export in Malaria Parasites." Nature 511, no. 7511 (2014): 587–91. Gold, D. A., A. D. Kaplan, et al. "The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole." Cell Host & Microbe 17, no. 5 (2015): 642–52. |
| 5 |
The transforming parasite: How Theileria modifies its host cell in order to replicate |
Dessauge, F., S. Hilaly, et al. "c-Myc Activation by Theileria Parasites Promotes Survival of infected B-lymphocytes." Oncogene 24, no. 6 (2005): 1075–83. (Nature Publishing Group) Marsolier, J., M. Perichon, et al. "Theileria Parasites Secrete a Prolyl Isomerase to Maintain Host Leukocyte Transformation." Nature 520, no. 7547 (2015): 378–82. |
| 6 |
(Don't) Divide and Conquer: How Toxoplasma pauses the host cell cycle |
Brunet, J., A. W. Pfaff, et al. "Toxoplasma Gondii Exploits UHRF1 and Induces Host Cell Cycle Arrest at G2 to Enable its Proliferation." Cellular Microbiology 10, no. 4 (2008): 908–20. (Blackwell Publishing Limited) Bougdour, A., E. Durandau, et al. "Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression." Cell Host & Microbe 13, no. 4 (2013): 489–500. |
| 7 |
Field Trip | No Readings |
| 8 |
Jamming communications: Strategies to thwart innate immunity |
Lambert, H., N. Hitziger, et al. "Induction of Dendritic Cell Migration upon Toxoplasma Gondii Infection Potentiates Parasite Dissemination." Cellular Microbiology 8, no. 10 (2006): 1611–23. (Blackwell Publishing Limited) Etheridge, R. D., A. Alaganan, et al. "The Toxoplasma Pseudokinase ROP5 Forms Complexes With ROP18 and ROP17 Kinases that Synergize to Control Acute Virulence in Mice." Cell Host & Microbe 15, no. 5 (2014): 537–50. |
| 9 |
The fatal consequences of hide and seek: How changes in Plasmodium's surface increases disease severity |
Lavstsen, T., L. Turner, et al. "Plasmodium Falciparum Erythrocyte Membrane Protein 1 Domain Cassettes 8 and 13 are Associated With Severe Malaria in Children." Proceedings of the National Academy of Sciences of the United States of America 109, no. 26 (2012): E1791–800. (National Academy of Sciences) Avril, M., A. K. Tripathi, et al. "A Restricted Subset of Var Genes Mediates Adherence of Plasmodium Falciparum-Infected Erythrocytes to Brain Endothelial Cells." Proceedings of the National Academy of Sciences of the United States of America 109, no. 26 (2012): E1782–90. |
| 10 |
Malarial mind control–Plasmodium increases transmission by modifying mosquito behavior |
Cator, L. J., J. George, et al. "'Manipulation' Without the Parasite: Altered Feeding Behaviour of Mosquitoes is Not Dependent on Infection with Malaria Parasites." Proceedings. of the Royal Society B Biological Science 280, no. 1763 (2013): 20130711. (The Royal Society) De Moraes, C. M. Stanczyk, et al. "Malaria-Induced Changes in Host Odors Enhance Mosquito Attraction." Proceedings of the National Academy of Sciences of the United States of America 111, no. 30 (2014): 11079–84. (National Academy of Sciences) |
| 11 |
Of mice, rats, cats, leopards and chimpanzees |
Berdoy, M., J. P. Webster, et al. "Fatal Attraction in Rats Infected With Toxoplasma Gondii." Proceedings of the Royal Society B Biological Science 267, no. 1452 (2000): 1591–94. (The Royal Society) Poirotte, C., P. M. Kappeler, et al. "Morbid Attraction to Leopard Urine in Toxoplasma-Infected Chimpanzees." Current Biology 26, no. 3 (2016): R98–9. Prandovszky, E., E. Gaskell, et al. "The Neurotropic Parasite Toxoplasma Gondii Increases Dopamine Metabolism." PLoS ONE 6, no. 9 (2011): e23866. (Public Library of Science) |
| 12 |
Oral presentations | No Readings |