Readings

SES # TOPICS READINGS
1 Overview and distribution of papers
2 Phagocytosis

Alpuchearanda, C. M., Racoosin, E. L., Swanson, J. A., and Miller, S. I. "Salmonella Stimulate Macrophage Macropinocytosis and Persist within Spacious Phagosomes." Journal of Experimental Medicine 179 (1994): 601-608.

Harrison, R. E., Brumell, J. H., Khandani, A., Bucci, C., Scott, C. C., Jiang, X. J., Finlay, B. B., and Grinstein, S. L. "Salmonella Impairs RILP Recruitment to Rab7 during Maturation of Invasion Vacuoles." Molecular Biology of the Cell 15 (2004): 3146-3154.

3 Toll-like receptors (TLRs)

Stack, J., Haga, I. R., Schroder, M., Bartlett, N. W., Maloney, G., Reading, P. C., Fitzgerald, K. A., Smith, G. L., and Bowie, A. G. "Vaccinia Virus Protein Toll-like-interleukin-1 A46R Targets Multiple Receptor Adaptors and Contributes to Virulence." Journal of Experimental Medicine 201 (2005): 1007-1018.

Tomizawa, H., Takeda, K., and Akira, S. "Small Anti-viral Compounds Activate Immune Cells via the TLR7 MyD88-dependent Signaling Pathway." Nature Immunology 3 (2002): 196-200.

4 The proteasome and ubiquitin

Kattenhorn, L. M., Korbel, G. A., Kessler, B. M., Spooner, E., and Ploegh, H. L. "A Deubiquitinating Enzyme Encoded by HSV-1 belongs to a Family of Cysteine Proteases that is conserved across the Family Herpesviridae." Molecular Cell 19 (2005): 547-557.

Zhou, H. L., Monack, D. M., Kayagaki, N., Wertz, I., Yin, J. P., Wolf, B., and Dixit, V. M. "Yersinia Virulence Factor YopJ acts as a Deubiquitinase to Inhibit NF-kappa B Activation." Journal of Experimental Medicine 202 (2005): 1327-1332.

5 Major histocompatibility (MHC) class I antigen presentation

Wiertz, E., Jones, T. R., Sun, L., Bogyo, M., Geuze, H. J., and Ploegh, H. L. "The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol." Cell 84 (1996): 769-779.

Ye, Y. H., Shibata, Y., Yun, C., Ron, D., and Rapoport, T. A. "A Membrane Protein Complex Mediates Retro-translocation from the ER Lumen into the Cytosol." Nature 429 (2004): 841-847.

6 Major histocompatiblity (MHC) class II antigen presentation

Nef. Garcia, J. V., and Miller, A. D. "Serine Phosphorylation-independent Down-regulation of Cell-surface CD4." Nature 350 (1991): 508-511.

Pancio, H. A., Vander Heyden, N., Kosuri, K., Cresswell, P., and Ratner, L. "Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain." Journal of Virology 74 (2000): 6168-6172.

7 Cytokines

Kledal, T. N., Rosenkilde, M. M., Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Power, C. A., Luttichau, H. R., Gerstoft, J., Clapham, P. R., ClarkLewis, I., Wells, T. N. C., and Schwartz, T. W. "A Broad-spectrum Chemokine Antagonist Encoded by Kaposi's Sarcoma-associated Herpesvirus." Science 277 (1997): 1656-1659.

Deng, H. K., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., DiMarzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. B., Peiper, S. C., Schall, T. J., Littman, D. R., and Landau, N. R. "Identification of a Major Co-receptor for Primary Isolates of HIV-1." Nature 381 (1996): 661-666.

8 Programmed cell death

Everett, H., Barry, M., Lee, S. F., Sun, X. J., Graham, K., Stone, J., Bleackley, R. C., and McFadden, G. "M11L: A Novel Mitochondria-localized Protein of Myxoma Virus that Blocks Apoptosis of Infected Leukocytes." Journal of Experimental Medicine 191 (2000): 1487-1498.

Henderson, S., Rowe, M., Gregory, C., Croomcarter, D., Wang, F., Longnecker, R., Kieff, E., and Rickinson, A. " Induction of Bcl-2 Expression by Epstein-Barr-Virus Latent Membrane Protein-1 Protects Infected B-cells from Programmed Cell-death." Cell 65 (1991): 1107-1115.

9 Molecular mimicry

Reyburn, H. T., Mandelboim, O., ValesGomez, M., Davis, D. M., Pazmany, L., and Strominger, J. L. "The Class I MHC Homologue of Human Cytomegalovirus inhibits attack by Natural Killer Cells." Nature 386 (1997): 514-517.

Cosman, D., Fanger, N., Borges, L., Kubin, M., Chin, W., Peterson, L., and Hsu, M. L." A Novel Immunoglobulin Superfamily Receptor for Cellular and Viral MHC Class I Molecules." Immunity 7 (1997): 273-282.

10 Antimicrobial peptides: Innate immunity effectors

Bader, M. W., Sanowar, S., Daley, M. E., Schneider, A. R., Cho, U. S., Xu, W. Q., Klevit, R. E., Le Moual, H., and Miller, S. "Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase." Cell 122 (2005): 461-472.

Legarda, D., Klein-Patel, M. E., Yim, S., Yuk, M. H., and Diamond, G. "Suppression of NF-kappa B-mediated Beta-defensin Gene Expression in the Mammalian Airway by the Bordetella Type III Secretion System." Cellular Microbiology 7 (2005): 489-497.

11 Oral presentation
12 Oral presentation and general discussion