Lecture Notes

LEC #          TOPICS                                             
1 Introduction (PDF)
2 Discovery of the Ubiquitin Conjugation System (PDF)
3 Protein Degradation in Trafficking Membranes I: Endoplasmic Reticulum Associated Degradation (ERAD) Pathway (PDF)
4 Protein Degradation in Trafficking Membranes II: Endocytosis and lysosomal Degradation (PDF)
5 Role of Ubiquitination in Transcriptional Regulation (PDF)
6 Role of Ubiquitination in Cell Cycle Control and Programmed Cell Death (PDF)
7 Ubiquitin-like Proteins (PDF)
8 Functions of the Ubiquitin-Proteasome System in the Immune System (PDF)
9 Ubiquitin and Cancer (PDF)
10 Ubiquitin and Neurodegenerative Diseases: Alzheimer's and Parkinson's Diseases (PDF)
11 More Diseases Involving Ubiquitin: Huntington's and Von Hippel-Lindau Disease (PDF)
12 Too Much Degradation Can Be as Bad as Not Enough: Cystic Fibrosis and Liddle's Syndrome (PDF)
13 Potential Therapeutic Strategies in Ubiquitin-Related Diseases (PDF)
14 Oral Presentations

Final Comments and Course Evaluation