This page lists the readings assigned per class session. Chapters from the course textbook are cited as:
|I. Tissue environment of the implanted biomaterial: unit cell processes|
|1||Survey of clinical cases of biomaterials-tissue interactions||Class notes: "Survey of Clinical Cases of Biomaterials-Tissue Interactions: The Paradigm." (PDF)|
Tissue structures and unit cell processes
Integrins and adhesion proteins
Class notes: "Tissue Structure/Unit Cell Processes." (PDF)
Giancotti, F. G., and E. Ruoslahti. "Integrin Signaling." Science 285 (August 13, 1999): 1028-1032.
Ruoslathi, E., and M. D. Pierschbacher. "New Perspectives in Cell Adhesion: RGD and Integrins." Science 238, no. 4826 (October 23, 1987): 491-497.
|3||Unit cell processes comprising the healing response||
Class notes: "Unit Cell Processes in the Tissue Environment." (PDF)
Gehrig, L., and M. I. O'Connor. "Putting Sex in Your Orthopaedic Practice." AAOS Now, June 2008.
|4||Unit cell processes underlying tissue engineering|
|5||Structure and function of naturally occurring ECMs||
Di Lullo, G. A., et al. "Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen." J Biol Chem 277, no. 6, I (February 8, 2002): 4223-4231.
Emsley, J., et al. "Structural Basis of Collagen Recognition by Integrin α2β1." Cell 101 (March 31, 2000): 47-56.
Knight, C. Graham. "The Collagen-binding A-domains of Integrins α1β1 and α2β1 Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens." J Biol Chem 275, no. 1 (January 7, 2000): 35-40.
Darnell, J. E., H. F. Lodish, and D. Baltimore. "Laminin, Fibronectin and Other Multiadhesive Matrix Glycoproteins." Chapter 23.4 in Molecular Cell Biology. 2nd ed. New York, NY: W. H. Freeman, 1990, pp. 920-924. ISBN: 9780716719816.
|6||ECM does not regenerate spontaneously||[TORA], Chapters 1 and 2|
|II. Cell-surface interactions|
|8||Analysis of surfaces of biomaterials and protein adsorption||
Class notes: "Characteristics of the Surfaces of Biomaterials." (PDF)
Class notes: "Methodology for Chemical Analysis of Surfaces." (PDF)
Ratner, B. D. "Surface Properties of Biomaterials." In Biomaterials Science: An Introduction to Materials. Edited by B. D. Ratner et al. Burlington, MA: Academic Press, 1996, pp. 21-35. ISBN: 9780125824606. [Preview in Google Books]
Andrade, J. D., ed. Excerpts from "Principles of Protein Adsorption." Chapter 1 in Surface and Interfacial Aspects of Biomedical Polymers, Vol. 2. Protein Adsorption. New York, NY: Plenum Press, 1985. ISBN: 9780306417412.
|9||Phenotype changes following adhesion on biomaterials|
|10||Structural determinants of biologically active materials|
|11||Methodology for cell-surface interactions|
|12||Cell-scaffold interactions during regeneration||
[TORA], Chapters 9 and 10
Freyman, T. M., I. V. Yannas, R. Yokoo, and L. J. Gibson. "Fibroblast Contraction of a Collagen-GAG Matrix." Biomaterials 22 (2001): 2883-2891.
Freyman, T. M., I. V. Yannas, Y-S. Pek, R. Yokoo, and L. J. Gibson. "Micromechanics of Fibroblast Contraction of a Collagen-GAG Matrix." Experimental Cell Research 269 (2001): 140-153.
Freyman, T. M., I. V. Yannas, R. Yokoo, and L. J. Gibson. "Fibroblast Contractile Force Is Independent of the Stiffness Which Resists the Contraction." Experimental Cell Research 272 (2002): 153-162.
|13||Noncooperative cell-surface interactions|
|14||From randomness to cooperativity|
|III. In vivo and clinical case studies|
|16||Tissue response to implants; biocompatibility||
Dolores, W., et al. "Cellular and Molecular Composition of Fibrous Capsules Formed Around Silicone Breast Implants with Special Focus on Local Immune Reactions." Journal of Autoimmunity 23, no. 1 (2004): 81-91.
Gordon, S., and P. R. Taylor. "Monocyte and Macrophage Heterogeneity." Nature Reviews Immunology 5 (December 2005): 953-964.
Spector, M., and P. A. Lalor. "In Vivo Assessment of Tissue Compatibility." Chapter 5.3 in Biomaterials Science: An Introduction to Materials. Edited by B. D. Ratner, et al. Burlington, MA: Academic Press, 1996, pp. 220-228. ISBN: 9780125824606. [Preview in Google Books]
|17||Epithelialization (epidermal regeneration) and endothelialization of vascular prostheses|| |
Buter, C. E., D. P. Orgill, I. V. Yannas, and C. C. Compton. "Effect of Keratinocyte Seeding of Collagen-Glycosaminoglycan Membranes on the Regeneration of Skin in a Porcine Model." Plastic & Recontructive Surgery 101, no. 6 (May 1998): 1572-1579.
|18||In vivo synthesis of skin||[TORA], Chapter 5|
|19||In vivo synthesis of peripheral nerve||
[TORA], Chapter 6
Yannas, I. V., M. Zhang, and M. H. Spilker. "Standardized Criterion to Analyze and Directly Compare Various Materials and Models for Peripheral Nerve Regeneration." J Biomater Sci, Polymer Edn 18, no. 8 (2007): 943-966.
|20||Rules for synthesis of tissues and organs||[TORA], Chapter 7|
|21||Joints and dental tissues: prosthetic replacement|
|22||Implants for bone regeneration|
|23||Regeneration of soft musculoskeletal tissues|
|24||Biomaterial applications in the heart and other organs|